Rx Summary: Tirzepatide/Niacinamide 

Type of Injection: Subcutaneous

Frequency of Injection: Weekly (or as directed by your provider)

Optimal Storage: Refrigeration

BUD: Up to 8 months on average

Information on Tirzepatide 

Information on Niacinamide

CUSTOMIZABLE DOSING PLAN

Recommended Dosing Schedule for Initiation of Treatment:

2mg once weekly for 2 weeks

4mg once weekly for 4 weeks (you should remain at this dose longer if you are losing weight consistently)

6mg once weekly for 3 weeks

Recommended Dosing Titration:

Increase by 2mg every 3-4 weeks as needed to a maximum dose of 14mg/week. If you have adequate appetite suppression at your current dose, you do not need to continue to increase. If you are sensitive to the medication or are experiencing any side effects, do not increase your dose. If you had sensitivities to the medication during any point of treatment, you can increase by only 1mg at a time if desired.

TRADITIONAL DOSING PLAN

Recommended Dosing Schedule for Initiation of Treatment:

2.5mg once weekly for 4 weeks

5mg once weekly for 4 weeks

Recommended Dosing Titration:

Increase by 2.5mg every 3-4 weeks as needed to a maximum dose of 15mg/week. If you have adequate appetite suppression at your current dose, you do not need to continue to increase. If you are sensitive to the medication or are experiencing any side effects, do not increase your dose. If you had sensitivities to the medication during any point of treatment, you can increase by only 5-10 units at a time if desired.

Below are the units you should administer based on the dose you are trying to achieve. Please note there are two concentrations (mg/mL). Always check your vial prior to injecting to ensure you are going by the correct concentration. The traditional dosing schedule doses are highlighted in purple.

8/2 mg/mL Concentration

1mg = 12 units

2mg = 25 units

2.5mg = 31 units

3mg = 37 units

4mg = 50 units

5mg = 62 units

6mg = 75 units

7mg = 87 units

7.5mg = 94 units

8mg = 100 units

9mg = 112 units (1.12mL)

10mg = 125 units (1.25mL)

17/2 mg/mL Concentration

5mg = 29 units

6mg = 35 units

7 mg = 41 units

7.5mg = 44 units

8mg = 47 units

9mg = 53 units

10mg = 59 units

11mg = 65 units

12mg = 70 units

12.5mg = 74 units

13mg = 77 units

14mg = 82 units

15mg = 88 units

TIER 1 | 40mg total

• Custom Dosing: 9 week supply for those initiating treatment, 10 week supply at 4mg/week

• Traditional Dosing: 8 week supply at 5mg/week

• supplied in two 2.5mL vials at a concentration of 8/2 mg/mL

TIER 2 | 60mg total

• Custom Dosing: 10 week supply at 6mg/week

• Traditional Dosing: 8 week supply at 7.5mg/week

• supplied in three 2.5mL vials at a concentration of 8/2 mg/mL

TIER 3 | 80mg total

• Custom Dosing: 10 week supply at 8mg/week, 8 week supply at 10mg/week

• Traditional Dosing: 8 week supply at 10mg/week

• supplied in four 2.5mL vials at a concentration of 8/2 mg/mL

TIER 4 | 136mg total

• Custom Dosing: 11 week supply at 12mg/week, 9 week supply at 14mg/week

• Traditional Dosing: 10 week supply at 12.5mg/week, 9 week supply at 15mg/week

• supplied in two 4mL vials at a concentration of 17/2 mg/mL

EXTENDED DOSING PACKAGE (MID) | 102mg total

• Available to established patients only

• supplied in three 2mL vials at a concentration of 17/2 mg/mL

EXTENDED DOSING PACKAGE (HIGH) | 204mg total

• Available to established patients only who have had an order at Tier 2 (or equivalent) or higher

• supplied in three 4mL vials at a concentration of 17/2 mg/mL