Sublingual Semaglutide

Strive Sublingual Semaglutide

Semaglutide is a medication belonging to the class of drugs known as GLP-1 (glucagon-like peptide-1) receptor agonists. It is used for chronic weight management. It works by increasing insulin production and lowering glucagon secretion as well as targeting areas in the brain that regulates appetite and food intake. A small change in the molecule allows the drug to last weeks in our bodies rather than the natural version our bodies make, which lasts minutes.

How Does Semaglutide Work?

• Delays how quickly the stomach digests food, leading to a feeling of fullness and satisfaction with smaller meal sizes

• Stimulates insulin secretion by the pancreas

• Lowers blood sugar, in part by reducing the production of glucose in the liver

• Decreases inflammation throughout the body, which leads to adiponectin release and fat lipolysis

Benefits of Oral Sublingual Drops/Liquid

• Sublingual drops are easy to administer and are especially useful for patients who have an aversion to injections. The sublingual drops allow for ease of dose adjustments.

• Sublingual administration allows the medication to be absorbed directly into the bloodstream through the mucous membranes under the tongue, bypassing the gastrointestinal tract and liver metabolism (first-pass effect).

• The ease of use and the faster onset of effects can lead to better adherence to the treatment regimen.

Administration

Shake well before using. Place the prescribed amount of medication (mL) under the tongue one time daily and hold them there for at least 1-2 minutes. This allows the medication to be absorbed through the mucous membranes. Consistent use at the same time each day is recommended for optimal results.

DOSING: The starting dose is 0.5mg daily for 30 days, followed by 1mg daily. You can titrate up to a max dose of 2.5mg daily.

STORAGE: Refrigerate the drops, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use.

BE YOND USE DATE: 90 days

Side Effects

Common Side Effects:

Nausea, vomiting, diarrhea, and constipation are common but usually decrease over time.

Serious Side Effects:

Seek medical attention if you experience symptoms of pancreatitis (severe abdominal pain), gallbladder problems, or allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing).

WARNINGS:

Risk of Thyroid C-Cell Tumors: Semaglutide, like other GLP-1 receptor agonists, has been shown to cause thyroid C-cell tumors in rodents. However, it is not known if this risk is applicable to humans. Nonetheless, caution is advised.

Contraindications: Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).