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Naltrexone
Low-dose naltrexone (LDN) provides a temporary blockade of opioid receptors resulting in a rebound effect, yielding an increase in endorphin production. This boost in endorphins promotes healing, regulates immunity, provides pain relief, and reduces inflammation. Therapeutic benefits of LDN are evident in autoimmune diseases, gastrointestinal disorders, chronic pain, mental health challenges, and inflammation. It is also showing promising results in augmentation of medication assisted weight loss therapy through reduction of food cravings.
Common Dosing: Take 1.5 mg by mouth at bedtime for 7 to 14 days, then increase to 3 mg at bedtime for 7 to 14 days, then increase to 4.5 mg at bedtime thereafter. Optimal dosing is patient specific and not every patient will start at or maintain the same dosing schedule.
Warnings: LDN can cause vivid dreams the first few weeks of therapy. Most common side effects include fatigue, insomnia, flu-like symptoms, decreased appetite, anxiety, headache, or dizziness. Do not use LDN treatment in patients who are receiving opioid analgesics, dependent on opioids, and those individuals who have failed the naloxone challenge test or who have a positive urine screen for opioids.
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